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  • Designing and implementing sample and data collection for an international genetics study : the Type 1 Diabetes Genetics Consortium (T1DGC)
    Hilner, Joan E ...
    Bacground and purpose: The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon ... the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods: T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center,with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetesand Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results: T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations: Participation in T1DGC wasdeclined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. (Abs. trunc. at 2000 ch.)
    Vir: Clinical trials. - ISSN 1740-7745 (Letn. 7, št. 1, suppl. 5, 2010, str. S5-S32)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 27647705
    DOI

vir: Clinical trials. - ISSN 1740-7745 (Letn. 7, št. 1, suppl. 5, 2010, str. S5-S32)
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