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  • Induction/engineering, detection, selection, and expansion of clinical-grade human antigen-specific cd8+ cytotoxic t cell clones for adoptive immunotherapy
    Jeras, Matjaž ...
    Adoptive transfer of effector antigen-specific immune cells is becoming a promising treatment option in allogeneic transplantation, infectious diseases,cancer, and autoimmune disorders. Within this ... context, the important role of CD8+ cytotoxic T cells (CTLs) is objective of intensive studies directed to their in vivo and ex vivo induction, detection, selection, expansion, and therapeutic effectiveness. Additional questions that are being addressed by the scientific community are related to the establishment and maintenance of their longevity and memory state as well as to defining critical conditions underlying their transitions between discrete, but functionally different subtypes. In this article we review and comment latest approaches and techniques used for preparing large amounts of antigen-specific CTLs, suitable for clinical use.
    Vir: Journal of Biomedicine and Biotechnology. - ISSN 1110-7243 (Vol. 2010, 2010, str.705215-1-705215-15)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 2805361
    DOI

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