VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
13.
Izražanje receptorjev TLR4 v senzoričnih nevronih, ki oživčujejo vneto dlesen, pri podgani = TLR4 expression in sensory neurons innervating inflamed gingiva in the rat
Vindiš, Bojan ...
Background: Sensory neurons regulate different local inflammatory reactions, also periodontitis. Toll-like receptors (TLR) play a key role in the early phase of this response. TLR expression in ...neurons is up-regulated in various pathological conditions. We aimed to determine whether neurons innervating gingiva express TLR4, a receptor recognizing the polysaccharides of Gram-negative bacteria, and whether this expression is influenced by periodontitis. Materials and methods: Adult female Wistar rats were used (n = 10). Sensory neurons innervating gingiva were labelled with a retrograde marker, Fluoro-Gold (FG), applied to the gingiva of the right upper molar. In the experimental group (n = 5), periodontitis was induced by ligatures left inplace for ten days. FGcontaining neurons were identified in histological sections of trigeminal ganglia, and their TLR4 content was evaluated by immunohistochemical methods. Results: TLR4 was expressed in 12% of neurons innnervating intact gingiva (control group) and in 24% of neurons innervating inflamed gingiva (experimental group). In the experimental group, TLR4 expression was increased especially in middle-sized neurons, where it was 3.4 times more frequent than in the control group. Conclusion: Up-regulation of TLR4 expression in smaller sensory neurons projecting into inflamed gingiva suggests that nociceptors may be sensitized in inflammation. In addition, TLR4-mediated activation of neurons could affect the neurogenic mechanisms that regulate periodontitis.
Bibliografsko gradivo je bilo uspešno dodano na polico.
Dodajanje bibliografskega gradiva na polico ni uspelo.
Gradivo je že na polici.
Trajna povezava
URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto
Faktor vpliva
Izdaja
Kategorija
Razvrstitev
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Izberite knjižnično izkaznico:
Baze podatkov,
v katerih je revija indeksirana
Ime baze podatkov
Področje
Leto
Povezave do osebnih bibliografij avtorjev
Povezave do podatkov o raziskovalcih v sistemu SICRIS
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Citiranje
Funkcionalnost trenutno ni na voljo. Prosimo, poskusite kasneje.
