VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis
    Vega-Ruiz, Arturo ...
    Gain-of-function D816V point mutation within the kinase domain of the transmembrane receptor KIT is found in the great majority of patients with systemic mastocytosis (SM) and is attractive ... therapeutic target. Twenty patients with SM were enrolled during 2003-2005 in phase II clinical trial with imatinib mesylate (400mg daily), a KIT inhibitor. Median time on therapy was 9 months (range, 0.5-44+). Only one patient, with D816V KIT mutation-negative FIP1L1-PDGFRalpha-negative SM-HES, achieved complete remission (now lasting for 44 months). Six other patients reported symptomaticimprovement, including two with D816V KIT mutation-positive SM (onereported improvement in diarrhea and the other in fatigue). Other patientshad no benefit. Imatinib was relatively well tolerated. Our study confirms that imatinib therapy does not result in appreciable clinical activity in patients with D816V mutation-positive SM, but may result in a significant benefit in occasional patient with D816V mutation-negative SM.
    Vir: Leukemia Research. - ISSN 0145-2126 (Vol. 33, issue 11, 2009, str. 1481-1484)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 28175065

vir: Leukemia Research. - ISSN 0145-2126 (Vol. 33, issue 11, 2009, str. 1481-1484)
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