VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Predictive value of multidrug resistance proteins, topoisomerases II and ERCC1 in small cell lung cancer : a systematic review
    Knez, Lea, 1981- ...
    In small-cell lung cancer (SCLC), resistance to cancer drugs presents a major problem, limiting the effectiveness of chemotherapy. A better understanding ofthe molecular biology is essential to ... improve currently available cytotoxic therapy. Herein, a systematic review of studies evaluating the predictive value of multidrug resistance-associated proteins (MDR1, MRP1, MRP2 and MVP), topoisomerase II and ERCC1 for chemotherapy outcomes is presented. The role ofMDR1, MRP1 and MRP2 as predictive markers in SCLC has not yet been elucidated. The majority of studies reported an association between protein orgene expression and response to chemotherapy; however, the evidence is limited to univariate analyses performed in the frame of small retrospective trials. In addition, the largest trial did not confirm an independent predictive value for response rates or survival. Genetic variability may be overseen as a more promising marker. Available data on the predictive value oftopoisomerase II are scarce and in contrast to the general idea that higherprotein or gene expression correlate with greater chemo-sensitivity. Thedata on a possible predictive value of ERCC1 are also quite limited; in tworetrospective studies, ERCC1 turned out to be a significant predictive marker for survival, but only for limited disease patients. In conclusion, a continuous research, with standardized and validated methodology of markers' determination, should be aspired at all times; a better understanding of the biology of SCLC is of utmost importance to enable personalized therapy and to improve survival rates in this, so far, poorly controlled disease.
    Vir: Lung cancer. - ISSN 0169-5002 (Vol. 72, issue 3, 2011, str. 271-279)
    Vrsta gradiva - članek, sestavni del
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 28546777
    DOI

vir: Lung cancer. - ISSN 0169-5002 (Vol. 72, issue 3, 2011, str. 271-279)
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