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  • Deficiency of mast cells in coronary artery endarterectomy of male patients with type 2 diabetes [Elektronski vir]
    Pleskovič, Aleš ...
    Background: Type 2 diabetes is an important risk factor for the development ofcoronary artery disease (CAD). Focal or diffuse inflammation is often present in the vessels of patients with CAD. Mast ... cells are frequently presentin the plaques as well as in the inflammatory infiltrates in the atherosclerotic vessel wall. In the study we wanted to examine whether there are differences in the morphology, number and distribution of mast cells and in their ability to modify the atherosclerotic process in coronary arteries (CA) in the diabetic vs. the hypertensive population of patients with CAD. Methods: Coronary artery endarterectomy specimens were obtained from patientswith diabetes or hypertension as the only risk factor for CAD. The specimens were stained with haematoxylin-eosin and Sulphated Alcian Blue for mast cells and with immunofluorescent methods for fibrinogen-fibrin and IgG deposits in the vessel wall. Both morphological and stereological assessments were conducted for mast cells and mononuclear cell infiltrates. Results: The histological analysis of the vessel wall of diabetic patients in comparison with hypertensive patients showed a damaged endothelial cells layer and deposits of fibrin-fibrinogen and IgG in the tunica intima and media. The stereological count revealed a diminished numerical density of mast cells and a significantly higher volume density of the mononuclear cells. Mast cells displayed cytoplasmic vacuolization, extracellular extrusion of granule and pyknotic nuclei. Conclusion: This preliminary study suggests that the impairedmast cells might be the reason for more extensive inflammatory and immunologic atherosclerotic changes in the CA vessel wall of CAD patients withtype 2 diabetes.
    Vir: Cardiovascular diabetology [Elektronski vir]. - ISSN 1475-2840 (Vol. 10, 2011, str. 40)
    Vrsta gradiva - e-članek
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 28607705

    Povezava(-e):

    http://www.cardiab.com/content/10/1/40
    DOI

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