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  • MicroRNAs, innate immunity and ventricular rupture in human myocardial infarction
    Zidar, Nina, 1960- ...
    MicroRNAs are non-coding RNAs, functionioning as post-transcriptional regulators of gene expression. Some microRNAs have been demonstrated to play arole in regulation of innate immunity. After ... myocardial infarction (MI), innate immunity is activated leading to an acute inflammatory reaction. Thereis evidence that an intense inflammatory reaction might contribute to thedevelopment of ventricular rupture (VR) after MI. Using real-time PCR, we analysed the expression of miR-146a, miR-150, and miR-155 in autopsy samples of infarcted heart tissue from 50 patients with MI (23 with VR and 27 withoutVR). An altered expression of all three microRNAs was found in MI compared to the normal hearts. Comparing MI patients with VR and those withoutVR, we found miR-146a up-regulation, and miR-150 and miR-155 down-regulation in patients with VR. In conclusion, our study demonstrated an altered expression of miR-146a, miR-150, and miR-155 in MI compared to the normal hearts. These microRNAs are involved in regulation of the innate immunity. Differential expression of these microRNAs in MI patients with VR incomparison to those without VR provides further evidence that innate immunity resulting in an intense inflammatory reaction plays an important rolein the pathogenesis of VR after MI in humans.
    Vir: Disease markers. - ISSN 0278-0240 (Vol. 31, issue 5, 2011, str. 259-265)
    Vrsta gradiva - članek, sestavni del
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 29193689
    DOI

vir: Disease markers. - ISSN 0278-0240 (Vol. 31, issue 5, 2011, str. 259-265)
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