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Dose-modifying factor of radiation therapy with concurrent cisplatin treatment in HPV-positive squamous cell carcinoma : a preclinical studyPrevc, Ajda ...Human papillomavirus (HPV) is an important etiological factor in oropharyngeal squamous cell carcinoma (SCC). Compared to HPV-negative tumors, HPV-positive oropharyngeal SCC has shown a better ... response to nonsurgical treatments. In this study, we determined the dose-modifying factors for HPV-positive tumors with single-dose irradiation, with or without low radiosensitizing doses of cisplatin. In vitro, we determined an increased radiosensitivity of HPV-positive SCC, which might be a consequence of HPV-induced changes in the cell cycle regulation and DNA damage response, leading to increased cell death. Additionally, compared to HPV-negative tumors, 30% higher radiosensitivity of HPV-positive tumors was determined by tumor growth delay monitoring in immunodeficient mice in vivo. Concurrent cisplatin treatment had an additive effect in both HPV-negative and HPV-positive tumors, resulting in 20% better response in HPV-positive tumors than in HPV-negative tumors.Vir: Radiation research. - ISSN 0033-7587 (Vol. 189, iss. 6, Jun. 2018, str. 644-651)Vrsta gradiva - članek, sestavni delLeto - 2018Jezik - angleškiCOBISS.SI-ID - 2923643
Avtor
Prevc, Ajda |
Kranjc Brezar, Simona |
Čemažar, Maja |
Todorović, Vesna, 1982- |
Žegura, Bojana |
Novak, Matjaž, biologija, 1987- |
Filipič, Metka, 1954- |
Strojan Fležar, Margareta |
Srebotnik-Kirbiš, Irena |
Rotter, Ana |
Brožič, Andreja |
Nikšić Žakelj, Martina |
Poljak, Mario, 1965- |
Hošnjak, Lea |
Grošelj, Blaž |
Strojan, Primož |
Serša, Gregor
Teme
ploščatocelični rak |
humani papilomski virus |
rak grla |
cisplatin |
squamous cell carcinoma |
HPV |
oropharyngeal carcinoma |
cisplatin
Vnos na polico
Trajna povezava
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Faktor vpliva
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Prevc, Ajda | 37415 |
Kranjc Brezar, Simona | 19058 |
Čemažar, Maja | 14575 |
Todorović, Vesna, 1982- | 29469 |
Žegura, Bojana | 20767 |
Novak, Matjaž, biologija, 1987- | 34200 |
Filipič, Metka, 1954- | 09892 |
Strojan Fležar, Margareta | 14669 |
Srebotnik-Kirbiš, Irena | 19141 |
Rotter, Ana | 27503 |
Brožič, Andreja | 35354 |
Nikšić Žakelj, Martina | 38225 |
Poljak, Mario, 1965- | 11622 |
Hošnjak, Lea | 38525 |
Grošelj, Blaž | 38482 |
Strojan, Primož | 14576 |
Serša, Gregor | 08800 |
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