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  • Functional cell models of the gut and their applications in food microbiology : a review
    Cencič, Avrelija ; Langerholc, Tomaž, 1977-
    Animal experimentations has a long tradition for risk assessment of new drugs before they reach the clinic. To reduce expensive animal experimentation, attempts have been made to build inexpensive ... and convenient intestinal functional cell models to study toxicity and bioavailability of new substancesalong with providing relevant models to study interactions between the host, pathogens and intestinal microflora. We review the available cell lines and models of the intestine and their potential uses. Tumor derived celllines such as Caco-2, T84 and HT-29 are widely used despite many drawbacks, which are discussed with respect to complexity of the gut, where various cell types interact with commensal microbiota and gut-associated lymphoid tissue. To address this complexity, 3D models of human and animal gutrepresent a promising in vitro system to mimic in vitro situation without the use of transformed cell lines.
    Vir: International journal of food microbiology. - ISSN 0168-1605 (Letn. 141, 2010, str. S4-S14)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 2935596
    DOI

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