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A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetesNikolajević, Jovana ; Globočnik Petrovič, Mojca ; Petrovič, Danijel, 1963-Background: A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of arterial thrombosis, myocardial infarction, stroke and type 2 diabetes, but there is no evidence ... of association with diabetic retinopathy. The aim of this study was to examine the role of the PlA1/A2 polymorphism of the glycoprotein IIIa gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes. Design: Cross-sectional case-control study. Participants: Totally 222 patients with diabetic retinopathy and 120 diabetic subjects without clinical signs of diabetic retinopathy from the Eye Clinic, University Medical Centre Ljubljana were enrolled in the study. Methods: Fundus examination and blood biochemicalanalysis were performed. The polymerase chain reaction and restriction fragment length polymorphism were used. Main Outcome Measures: The total cholesterol, triglyceride, high-density lipoprotein levels, fasting blood glucose and HbA1c were measured, and the genotypes of the PlA1/A2 polymorphism were determined. Results: Patients with diabetic retinopathy hadearlier onset, longer duration of type 2 diabetes and a higher incidence ofinsulin therapy compared to the diabetic patients without diabetic retinopathy. A significantly lower frequency of the A2A2 genotype of glycoprotein IIIa was found in diabetic patients with retinopathy compared to those without retinopathy (odds ratio = 0.49, 95% confidence interval = 0.28-0.89; P = 0.018). Conclusions: The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes. Further studies are needed to elucidate its protective role in the development of diabetic retinopathy in Caucasians.Vir: Clinical & experimental ophthalmology. - ISSN 1442-6404 (Vol. 39, issue 7, 2011, str. 665-672)Vrsta gradiva - članek, sestavni delLeto - 2011Jezik - angleškiCOBISS.SI-ID - 29396441
Avtor
Nikolajević, Jovana |
Globočnik Petrovič, Mojca |
Petrovič, Danijel, 1963-
Teme
Diabetes Mellitus, Non-Insulin-Dependent |
Diabetic Retinopathy |
Glycoproteins |
Genetics |
Integrins |
Polymorphism, Restriction Fragment Length |
Polymerase Chain Reaction |
Blood Glucose |
Hemoglobin A, Glycosylated |
Cholesterol |
Triglycerides |
Lipoproteins, Hdl |
Cross-Sectional Studies |
Integrini |
Polimorfizem, omejene dolžine fragmentov |
Sladkorna bolezen, ne-inzulin-odvisna |
Diabetična retinopatija |
Glikoproteini |
Polimerazna, verižna reakcija |
Holesterol |
Krvni sladkor |
Hemoglobin A glikozilirani |
Presečne študije |
Trigliceridi |
Lipoproteini visoke gostote
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Nikolajević, Jovana | 31962 |
Globočnik Petrovič, Mojca | 20707 |
Petrovič, Danijel, 1963- | 11252 |
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