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  • Cerebrospinal fluid Alzheimer markers in depressed elderly subjects with and without Alzheimer's disease
    Gregorič Kramberger, Milica ...
    Background: The aim of this study was to explore the relationship between cerebrospinal fluid Alzheimerćs disease (AD) markers and depression in elderlypeople. Method: We included subjects with AD as ... well as persons with subjective cognitive impairment and normal cognition. Depression was assessed with the Cornell Scale for Depression in Dementia, and a cut-off score of 1 6 was used to define depression. Cerebrospinal fluid was analyzed using commercially available assays for beta-amyloid 1-42, total tau, and phosphorylated tau 181. Results: A total of 183 participants (66.7% female) were included (92 with AD and 91 with subjective cognitive impairment), with amean age ( +-SD) of 67.6 +- 7.4 years, a Mini-Mental State Examination score of 26.0 +- 4.0, and a median Cornell Scale for Depression in Dementia score of5 (range 0-19). Depression scores were not associated with higher phosphorylated tau 181 and total tau or reduced beta-amyloid 1-42 in AD or non-demented subjects. Conclusions: These results suggest that AD pathology does not contribute to depression, indicating that other factors may be more important. Further studies of the aetiology of depression in elderly people with and without AD are warranted.
    Vir: Dementia and geriatric cognitive disorders. - ISSN 1420-8008 (Vol. 2, iss. 1, 2012, str. 48-56)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 29602265
    DOI

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