VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Erythropoietin and erythropoiesis stimulating agents [Elektronski vir]
    Debeljak, Nataša ; Sytkowski, Arthur J.
    Erythropoietin (EPO) is the main hormonal regulator of red blood cell production. Recombinant EPO has become the leading drug for treatment of anaemia from a variety of causes; however, it is ... sometimes misused in sport with the aim of improving performance and endurance. This paper presents an introductory overview of EPO, its receptor, and a variety of recombinant humanEPOs/erythropoiesis stimulating agents (ESAs) available on the market (e.g. epoetins and their long acting analogs - darbepoetin alfa and continuouserythropoiesis receptor activator). Recent efforts to improve on EPO's pharmaceutical properties and to develop novel replacement products are also presented. In most cases, these efforts have emphasized a reduction in frequency of injections or complete elimination of intravenous or subcutaneousinjections of the hormone (biosimilars, EPO mimetic peptides, fusion proteins, endogenous EPO gene activators and gene doping). Isoelectric focusing (IEF) combined with double immunoblotting can detect the subtle differences in glycosylation/sialylation, enabling differentiation among endogenous and recombinant EPO analogues. This method, using the highly sensitive anti-EPO monoclonal antibody AE7A5, has been accepted internationally as one of the methods for detecting misuse of ESAs in sport. Copyright (c) 2012 John Wiley & Sons, Ltd.
    Vir: Drug testing and analysis. - ISSN 1942-7611 (Vol. 4, iss. 11, 2012, str. 805-812)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 29877209

    Povezava(-e):

    http://onlinelibrary.wiley.com/doi/10.1002/dta.1341/abstract
    DOI

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