VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • The pharmacological properties and therapeutic use of apomorphine
    Ribarič, Samo
    Apomorphine (APO) is an aporphine derivative used in human and veterinary medicine. APO activates D(1), D(2S), D(2L), D(3), D(4), and D(5) receptors (and is thus classified as a non-selective ... dopamine agonist), serotonin receptors (5HT(1A), 5HT(2A), 5HT(2B), and 5HT(2C)), and alpha-adrenergic receptors (alpha(1B), alpha(1D), alpha(2A), alpha(2B), and alpha(2C)). In veterinary medicine, APO is used to induce vomiting in dogs, an important early treatment for some common orally ingested poisons (e.g., anti-freeze or insecticides). In human medicine, it has been used in a variety of treatments ranging from the treatment of addiction (i.e., to heroin, alcohol or cigarettes), for treatment of erectile dysfunction in males and hypoactive sexual desire disorder in females to the treatment of patients with Parkinson's disease (PD). Currently, APO is used in patients with advanced PD,for the treatment of persistent and disabling motor fluctuations which do not respond to levodopa or other dopamine agonists, either on its own or in combination with deep brain stimulation. Recently, a new and potentially important therapeutic role for APO in the treatment of Alzheimer's disease hasbeen suggested; APO seems to stimulate Abeta catabolism in an animal modeland cell culture, thus reducing the rate of Abeta oligomerisation and consequent neural cell death.
    Vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 17, no. 5, 2012, str. 5289-5309)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 29971161

    Povezava(-e):

    Repozitorij Univerze v Ljubljani – RUL
    DOI

vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 17, no. 5, 2012, str. 5289-5309)
loading ...
loading ...
loading ...

Vnos na polico