-
Impact of ERCC1 expression on treatment outcome in small-cell lung cancer patients treated with platinum-based chemotherapySodja, Eva ...Introduction: The excision repair cross-complementing 1 (ERCC1) protein is an extensively investigated molecular marker because it may decrease sensitivity to platinum-based chemotherapy. Low ERCC1 ... expression has already been correlated with better treatment efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy. However, the data on a prognostic and/or predictive value of ERCC1 in small-cell lung cancer (SCLC) are still very limited. Methods: This retrospective pilot study evaluated the impact of ERCC1 expression levels on response to first-line platinum-based chemotherapy with or without radiotherapy and survival outcomes of 77 SCLC patients. ERCC1 protein expression was determined immunohistochemically in primary tumour tissue. Results: ERCC1 protein expression was positive in 40/77(51.9%) of our patients. No significant association was found between ERCC1 protein expression and response rate to first-line platinum-based chemotherapy, progression-free survival (PFS), or overall survival (OS), either in the overall population or in patients stratified by disease stage. Conclusions: In our limited group of 77 SCLC patients, ERCC1 protein expression was not found to correlate with either response rate to platinum-based chemotherapy or survival outcomes. Multi-centric prospective trials using a validated method of ERCC1 determination are mandatory in orderto obtain a definitive answer on the predictive value of ERCC1 in SCLC.Vir: European Journal of Cancer. - ISSN 0959-8049 (Vol. 48, iss. 18, 2012, str. 3378-3385)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2012Jezik - angleškiCOBISS.SI-ID - 30115033
Avtor
Sodja, Eva |
Knez, Lea, 1981- |
Kern, Izidor = Kern, Izidor |
Sadikov, Aleksander, računalništvo |
Čufer, Tanja, 1955-
Teme
Lung Neoplasms |
Drug Therapy |
Carcinoma, Small Cell |
Platinum |
Tumor Markers, Biological |
Immunohistochemistry |
Treatment Outcome |
Survival Analysis |
Tumorski označevalci biološki |
Imunohistokemija |
Pljučne novotvorbe |
Karcinom drobnocelični |
Platina |
Preživetje, analiza |
Zdravljenje, izid
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Sodja, Eva | 28517 |
Knez, Lea, 1981- | 29281 |
Kern, Izidor = Kern, Izidor | 15781 |
Sadikov, Aleksander, računalništvo | 20389 |
Čufer, Tanja, 1955- | 12179 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.