VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Detection of rare reassortant G5P[6] rotavirus, Bulgaria
    Mladenova, Zornitsa ...
    During the ongoing rotavirus strain surveillance program conducted in Bulgaria, an unusual human rotavirus A (RVA) strain, RVA/Human/BG/BG620/2008/G5Pš6đ, was identified among 2200 genotyped ... Bulgarian RVAs. This strain showed the following genomic configuration: G5-Pš6đ-I1-R1-C1-M1-A8-N1-T1-E1-H1. Phylogenetic analysis of the genes encoding the neutralization proteins and backbone genes identified a probable mixture of RVA genes of human and porcine origin. The VP1, VP6 and NSP2 geneswere more closely related to typical human rotavirus strains. The remaining eight genes were either closely related to typical porcine and unusual human-porcine reassortant rotavirus strains or were equally distant from reference human and porcine strains. This study is the first to report anunusual rotavirus isolate with G5Pš6đ genotype in Europe which has most likely emerged from zoonotic transmission. The absence of porcine rotavirus sequence data from this area did not permit to assess if the suspected ancestral zoonotic porcine strain already had human rotavirus genes in its genome when transmitted from pig to human, or, the transmission was coupled or followed by gene reassortment event(s). Because our strain shared no neutralization antigens with rotavirus vaccines used for routine immunization in children, attention is needed to monitor if this G-P combination will be able to emerge in human populations. A better understanding of the ecology of rotavirus zoonoses requires simultaneous monitoring of rotavirus strains in humans and animals.
    Vir: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. - ISSN 1567-1348 (Vol. 12, no. 8, 2012, str. 1676-1684)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 30180825
    DOI

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