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Proinflammatory effects of bare and PEGylated ORMOSIL-, PLGA- and SUV-NPs on monocytes and PMNs and their modulation by f-MLPSegat, Daniela ...We wanted to test the proinflammatory effects of vinyltriethoxysilane-based organically modified silica nanoparticles (ORMOSIL-NPs) in vitro on blood leukocytes. Materials & methods: Cell ... selectivity, cytokines/chemokines and O2- production were analyzed using nonpolyethylene glycol (PEG)ylated and PEGylated ORMOSIL-NPs, poly(lactic-co-glycolic acid) (PLGA)-NPs and small unilamellar vesicles (SUV)-NPs. Results: ORMOSIL-NPs mostly bound to monocytes while other NPs to all leukocyte types similarly. Cell capture of PEGylated-NPs decreased strongly (ORMOSIL), moderately (PLGA) and weakly (SUV). Bare ORMOSIL-NPs effectively stimulated the production of IL-1b/IL-6/TNF-a/IL-8 by monocytes and of IL-8 by polymorphonuclear leukocytes(PMNs). NP PEGylation inhibited such effects only partially. Formyl-methionine-leucine phenylalanine (f-MLP) further increased the release of cytokines/chemokines by monocytes/PMNs primed with bare and PEGylated ORMOSIL-NPs. PEGylated SUV-NPs, bare and PEGylated ORMOSIL- and PLGA-NPs sensitize PMNs and monocytes to secrete O2- upon f-MLP stimulation. Conclusion: ORMOSIL-NPs are preferentially captured by circulating monocytes but stimulate both monocytes and PMNs per se or by sensitizing them to another agonist (f-MLP). PEG-coating confers stealth effects but does not completely eliminate leukocyte activation. Safe nanomedical applications require the evaluation of both intrinsic and cooperative proinflammatory potential of NPs.Vir: Nanomedicine. - ISSN 1743-5889 (Vol. 6, no. 6, 2011, str. 1027-1046)Vrsta gradiva - članek, sestavni delLeto - 2011Jezik - angleškiCOBISS.SI-ID - 3033713
Avtor
Segat, Daniela |
Tavano, Regina |
Donini, Marta |
Rio-Echevarria, Iria |
Rojnik, Matija |
Kocbek, Petra, farmacevtka |
Kos, Janko, 1959- |
Iratni, Selma |
Schegelmann, Dietrich |
Mancin, Fabrizio |
Dusi, Stefano |
Papini, Emanuele
Teme
citokini |
ORMOSIL nanodelci |
PLGA nanodelci |
levkociti |
monociti |
diagnostika
Vnos na polico
Trajna povezava
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Segat, Daniela | |
Tavano, Regina | |
Donini, Marta | |
Rio-Echevarria, Iria | |
Rojnik, Matija | 31397 |
Kocbek, Petra, farmacevtka | 24402 |
Kos, Janko, 1959- | 04648 |
Iratni, Selma | |
Schegelmann, Dietrich | |
Mancin, Fabrizio | |
Dusi, Stefano | |
Papini, Emanuele |
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