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  • A flow cytometric analysis of vitreous inflammatory cells in patients with proliferative diabetic retinopathy [Elektronski vir]
    Urbančič, Mojca, 1967- ...
    The purpose of this study was to investigate inflammatory cells in vitreous from patients with proliferative diabetic retinopathy (PDR) using flow cytometric analysis. Twenty-eight patients with PDR ... requiring vitrectomy because of macular traction or tractional retinal detachment were enrolled in the study ( ), and 6 patients with macular hole (MH) formed the control group. Samples of vitreous and peripheral venous blood were obtained at the beginning of vitrectomy. T lymphocytes were found in vitreous from patients with PDR, and CD4/CD8 ratio was higher in vitreous (median 4.3) compared to blood (median 1.9; ). No B lymphocytes were detected in vitreous. The percentage of histiocytes/macrophages was significantly higher in vitreous (median 62.1) in comparison with blood (median 5.5; ). No lymphocytes were detected in vitreous of the control group. There were more T lymphocytes in vitreous from patients with active PDR. No association between cells in the vitreous and visual acuity improvement after surgery was found. In conclusion, T lymphocytes are found in vitreous from patients with PDR and reflect the activity of PDR but do not seem to predict visual prognosis. Higher CD4/CD8 ratio in vitreous compared to blood from patients with PDR is consistent with local inflammatory response in PDR.
    Vir: BioMed research international [Elektronski vir]. - ISSN 2314-6141 (Vol. 2013, 2013)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 30928089

    Povezava(-e):

    http://www.hindawi.com/journals/bmri/2013/251528/
    DOI

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