VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphoma
    Erčulj, Nina ...
    Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and ... methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTXrelated toxicity in children with NHL.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 48, no. 3, Sep. 2014, str. 289-292, V)
    Vrsta gradiva - članek, sestavni del
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 31525337

    Povezava(-e):

    http://www.degruyter.com/view/j/raon.2014.48.issue-3/raon-2013-0076/raon-2013-0076.xml?format=INT
    Digitalna knjižnica Slovenije - dLib.si
    DiRROS - Digitalni repozitorij raziskovalnih organizacij Slovenije

vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 48, no. 3, Sep. 2014, str. 289-292, V)
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