VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Genetic variability testing of neurodevelopmental genes in schizophrenic patients
    Terzič, Tea ...
    This study investigated the associations between single nucleotide polymorphisms in the neurodevelopmental Disrupted In Schizophrenia 1 ( DISC1 ), neuregulin 1 ( NRG1 ), brain-derived neurotrophic ... factor ( BDNF )and NOTCH4 genes and the clinical symptoms and the occur- rence of treatment-resistant schizophrenia in the Slovenian population. We included 138 schizophrenia patients, divid- ed into treatment-responsive a nd treatment-resistant group and 94 healthy blood donors. All subjects were genotyped for eight polymorphisms ( DISC1 rs6675281, DISC1 rs821616, NRG1 rs3735781, NRG1 rs3735782, NRG1 rs10503929, NRG1 rs3924999, BDNF rs6265, NOTCH rs367398) and investigated for associations with clinical variables. NOTCH4 rs367398 AA/AG was significantly associated with worse Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) score. NOTCH4 rs367398 was not statistically significant- ly associated with the occurrence of treatment-resistant schizophrenia after the correction for multiple testing. Our data indicate that NOTCH4 polymorphism can influ- ence clinical symptoms in Slovenian patients with schizophrenia
    Vir: Journal of molecular neuroscience. - ISSN 0895-8696 (Vol. 56, iss. 1, May 2015, str. 205-211)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 31770585

    Povezava(-e):

    http://link.springer.com/article/10.1007%2Fs12031-014-0482-5
    DOI

vir: Journal of molecular neuroscience. - ISSN 0895-8696 (Vol. 56, iss. 1, May 2015, str. 205-211)
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