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Interleukin-1[alpha] gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian peopleZupan, Janja, farmacevtka ...Background: Osteoporosis is a skeletal disorder, characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased risk of fracture. Recently, the role of ... age-related pro-infl ammatory cytokines, such as interleukin (IL)-1 Ž , in stimulating bone resorption has been suggested. As osteoporosis has a strong genetic background, the aim of our study was to evaluate the association of two IL-1 @gene single nucleotide polymorphisms (SNPs) rs2071375 ( + 12534G > A) and rs17651 ( + 4845G > T) with osteoporotic phenotypes as well as to fi nd the association with IL-1@ gene expression in human bone tissue. Methods: Genotyping was performed in 671 Slovenian participants, 125 elderly men, 490 post- and 56 premenopausal women. Bone mineral density (BMD) at the lumbar spine, femoral neck and total hip were measured. Biochemical markers of bone turnover were measured in women. Results: Signifi cant association of GG/TA haplotype with higher femoral neck and total hip BMD in elderly men and women was shown (p = 0.009 and 0.030, respectively). In men, the association of the GG/GG haplotype with higher femoral neck BMD was of limited statistical significance (p = 0.050). In women, significant association of studied genetic variants with serum C-terminal crosslinking telopeptides of type I collagen and bone alkaline phosphatase were found (p = 0.033 and 0.029, respectively). No infl uence on IL-1 Ž expression was found. Finally, signifi cantly lower odds ratio for hip fracture associated with the presence of TA haplotype was found (p = 0.026).Vir: Clinical chemistry and laboratory medicine. - ISSN 1434-6621 (Vol. 50, no. 8, 2012, str. 1379-1385)Vrsta gradiva - članek, sestavni delLeto - 2012Jezik - angleškiCOBISS.SI-ID - 3207793
Avtor
Zupan, Janja, farmacevtka |
Pristovšek, Nuša |
Mencej Bedrač, Simona |
Komadina, Radko |
Preželj, Janez |
Marc, Janja
Teme
osteoporoza |
kostna gostota |
vnetje |
rs17561 |
rs2071375
vir: Clinical chemistry and laboratory medicine. - ISSN 1434-6621 (Vol. 50, no. 8, 2012, str. 1379-1385)
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Zupan, Janja, farmacevtka | 32306 |
Pristovšek, Nuša | |
Mencej Bedrač, Simona | 24475 |
Komadina, Radko | 19380 |
Preželj, Janez | 01989 |
Marc, Janja | 12189 |
Vir: Osebne bibliografije
in: SICRIS
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