VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Intergenic Alu exonisation facilitates the evolution of tissue-specific transcript ends
    Tajnik, Mojca ...
    The 3' untranslated regions (3' UTRs) of transcripts serve as important hubs for posttranscriptional gene expression regulation. Here, we find that the exonisation of intergenic Alu elements ... introduced new terminal exons and polyadenylation sites during human genome evolution. While Alu exonisation from introns has been described previously, we shed light on a novel mechanism to create alternative 3' UTRs, thereby opening opportunities for differential posttranscriptional regulation. On the mechanistic level, we show that intergenic Alu exonisation can compete both with alternative splicing and polyadenylation in the upstream gene. Notably, the Alu-derived isoforms are often expressed in a tissue-specific manner, and the Alu-derived 3' UTRs can alter mRNA stability. In summary, we demonstrate that intergenic elements can affect processing of preceding genes, and elucidate how intergenic Alu exonisation can contribute to tissue-specific posttranscriptional regulation by expanding the repertoire of 3' UTRs.
    Vir: Nucleic acids research. - ISSN 0305-1048 (Vol. 43, no. 21, Dec. 2015, str. 10492-10505)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 32215257

    Povezava(-e):

    http://nar.oxfordjournals.org/content/early/2015/09/22/nar.gkv956.long
    DOI

vir: Nucleic acids research. - ISSN 0305-1048 (Vol. 43, no. 21, Dec. 2015, str. 10492-10505)
loading ...
loading ...
loading ...

Vnos na polico