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  • Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases
    Milisav, Irina ; Šuput, Dušan ; Ribarič, Samo
    Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis ... susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.
    Vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 20, no. 12, Oct. 2015, str. 22718-22756)
    Vrsta gradiva - članek, sestavni del
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 32400601

    Povezava(-e):

    http://www.mdpi.com/1420-3049/20/12/19865/htm
    Repozitorij Univerze v Ljubljani – RUL
    DOI

vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 20, no. 12, Oct. 2015, str. 22718-22756)
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