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  • Efficacy of CD34[sup]+ stem cell therapy in nonischemic dilated cardiomyopathy is absent in patients with diabetes but preserved in patients with insulin resistance
    Vrtovec, Bojan, 1972- ...
    We evaluated the association of diabetes and insulin resistance with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM). A total of 45 outpatients with DCM ... received granulocyte colony-stimulating factor for 5 days. CD34[sup]+ cells were then collected by apheresis and injected transendocardially. Twelve patients had diabetes mellitus (DM group), 17 had insulin resistance (IR group), and 16 displayed normal glucose metabolism (no-IR group). After stimulation, we found higher numbers of CD34[sup]+ cells in the IR group (94+-73x10[sup]6 cells per liter) than in the no-IR group (54 +- 35 x 10[sup]6 cells per liter) or DM group (31 +- 20 x 10[sup]6 cells per liter; p = .005). Similarly, apheresis yielded the highest numbers of CD34[sup]+ cells in the IR group (IR group, 216+-110x10[sup]6 cells; no-IR group, 127+-82x10[sup]6 cells; DMgroup, 77+-83x10[sup]6 cells; p = .002). Six months after cell therapy, we found an increase in left ventricular ejection fraction in the IR group (+5.6%+-6.9%) and the no-IR group (+4.4% + 7.2%) but not in the DM group (-0.9% +- 5.4%; p = .035). The N-terminal probrain natriuretic peptide levels decreased in the IR and no-IR groups, but not in the DMgroup (-606+- 850 pg/ml; -698 +- 1,105 pg/ml; and +238 +- 963 pg/ml, respectively; p = .034). Transendocardial CD34+ cell therapy appears to be ineffective in DCM patients with diabetes. IR was associated with improved CD34+ stem cell mobilization and a preserved clinical response to cell therapy.
    Vir: Stem cells translational medicine. - ISSN 2157-6564 (Vol. 5, no. 5, May 2016, str. 632-638)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 32541145

    Povezava(-e):

    https://authorcenter.dartmouthjournals.com/?key=qd5w7y
    DOI

vir: Stem cells translational medicine. - ISSN 2157-6564 (Vol. 5, no. 5, May 2016, str. 632-638)
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