VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Uravnavanje acetilholinesteraze in drugih sinaptičnih sestavin v skeletni mišici med regeneracijo : doktorska disertacija
    Črne-Finderle, Nevenka
    Muscle regeneration represents a short repetition of ontogenetic development from the myogenic stem cells to the innervated muscle fibers and can be used as a suitable experimental model to study ... biochemical characteristics of developing muscle cells. Therefore, ability to regulate acetylcholinesterase (AChE) either in absence or presence of innervation and ability of noninnervated muscle cells to form postsynaptic-apparatus-like sarcolemmal specializations was explored in regenerating muscles. Patterns and distribution of AChE molecular forms were studied in regenerating fast extensor digitorum longus (EDL) and slow soleus (SOL) muscle after ischaemic-toxic injury. AChE molecular forrns were analysed by velocity sedimentation in linear sucrose gradients. Histochemical and cytochemical methods were used to study localization and ultrastructure of focal accumulations of AChE in regenerating muscles. The extent of congruity with two other synaptic molecules, acetylcholine receptor (AChR) and Dolichos biflorus agglutinin binding glycoprotein (DBAR), was investigated. The patterns of AChE molecular forms in normal mature SOL and EDL muscles differ signifficantly, but no such differences were observed early in noninnerevated regenerating SOL and EDL muscles. All major AChE molecular forms were present in 8-day old noninnervated regenerating muscles. The 4S (G1) form predominatedbut the asymmetric A12 AChE molecular form contributed about 20 per cent of AChE activity. The activity of the lOS (G4) molecular form became predominant with increasing muscle maturation. These re sults show that immature regenerating myot from motor nerves. We assume that the satellite cells which gave rise to the regenerating myotubes originate from the late myoblasts and preserve their potential to synthesize the asymmetric AChE forms, inspite of long standstill and several divisions during regeneration.(abstract truncated at 2000 characters)
    Vrsta gradiva - disertacija
    Založništvo in izdelava - Ljubljana : [N. Črne-Finderle], 1992
    Jezik - slovenski
    COBISS.SI-ID - 32549120

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 2 izv.
Narodna in univerzitetna knjižnica, Ljubljana Ljubljana NUK v čitalnico 1 izv.
Univerzitetna knjižnica Maribor Maribor UKM v čitalnico 1 izv.
ni za izposojo 1 izv.
loading ...
loading ...
loading ...

Vnos na polico