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  • Recommending oral probiotics to reduce winter antibiotic prescriptions in people with asthma [Elektronski vir] : a pragmatic randomized controlled trial
    Smith, Timothy D. H. ...
    Purpose Evidence from studies mainly in children has shown that orally admin - istered probiotics may prevent respiratory tract infections and associated antibi - otic use. We evaluated whether ... advice to take daily probiotics can reduce antibi - otic prescribing for winter respiratory tract infections in people with asthma. Methods We conducted a randomized controlled, parallel-group pragmatic study for participants aged 5 years and older with asthma in a UK primary care setting. The intervention was a postal leaflet with advice to take daily probiotics from October 2013 to March 2014, compared with a standard winter advice leaf - let. Primary outcome was the proportion of participants prescribed antibiotics for respiratory tract infections. Results There were 1,302 participants randomly assigned to a control group (n = 650) or intervention group (n = 652). There was no significant differ - ence in the primary outcome measure, with 27.7% receiving antibiotics in the intervention group and 26.9% receiving antibiotics in the control group (odds ratio = 1.04; 95% CI, 0.82-1.34). Uptake of probiotics was low, but outcomes were similar in those who accessed probiotics (adjusted odds ratio = 1.08; 95% CI, 0.69-1.69, compared with controls). We also found no evidence of an effect on respiratory tract infections or asthma exacerbations. Conclusions In this pragmatic community-based trial in people with asthma, we found no evidence that advising use of winter probiotics reduces antibiotic prescribing.
    Vir: Annals of family medicine.. - ISSN 1544-1709 (Vol. 14, no. 5, Sep. 2016, str. 422-430)
    Vrsta gradiva - e-članek
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 32955609

    Povezava(-e):

    http://www.annfammed.org/content/14/5/422
    DOI

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