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  • Metal maps of sclerotic hippocampi of patients with mesial temporal lobe epilepsy
    Opačić, Miloš ...
    The loss of metal homeostasis has been implicated in the pathophysiology of mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). Here we applied laser ablation inductively ... coupled plasma mass spectrometry imaging to establish spatial distribution of Zn, Fe, Cu and Mn in coronal sections of hippocampi of four drug-resistant mTLE-HS patients who underwent amygdalohippocampectomy. Detailed maps of metal concentrations in different morphological areas/layers were built and analyzed. The highest level of Zn (>20 [micro]g/g) was found in mossy fibers-rich regions - cornu Ammonis field 4 (CA4), gyrus dentatus, and CA3. Distribution of Fe appears to reflect routes of main intrahippocampal blood vessels. The highest concentrations of Cu (>10 [micro]g/g) and Mn (>15 [micro]g/g) were observed in regions/layers with neuron somata - subiculum, CA4, gyrus dentatus, and stratum pyramidale (SPy) in CA1 and CA2. Alveus and other regions with axons and dendrites generally showed lower levels of Zn, Cu, and Mn. Cu concentration was decreased in the areas of total neuronal loss in SPy in CA1 (9.73 +- 0.91 [micro]g/g), compared to subiculum (13.32 +- 1.29 [micro]g/g; p = 0.043). Cu and Mn concentrations correlated positively with neuron density in SPy in CA1 (R = 0.629, p < 0.001; and R = 0.391, p = 0.004). These results provide a deeper insight into hippocampal metabolism of metals, and pave the road for identifying the components of the mechanism of epileptogenesis among Cu and Mn transporters and metalloproteins.
    Vir: Metallomics. - ISSN 1756-5901 (Vol. 9, iss. 2, Feb. 2017, str. 141-148)
    Vrsta gradiva - članek, sestavni del
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 33067737
    DOI

vir: Metallomics. - ISSN 1756-5901 (Vol. 9, iss. 2, Feb. 2017, str. 141-148)
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