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Store-operated calcium entry in mu Müller glia is controlled by synergistic activation of TRPC and orai channelsMolnar, Tünde ...The endoplasmic reticulum (ER) is at the epicenter of astrocyte Ca(2+) signaling. We sought to identify the molecular mechanism underlying store-operated calcium entry that replenishes ER stores in ... mouse Müller cells. Store depletion, induced through blockade of sequestration transporters in Ca(2+)-free saline, induced synergistic activation of canonical transient receptor potential 1 (TRPC1) and Orai channels. Store-operated TRPC1 channels were identified by their electrophysiological properties, pharmacological blockers, and ablation of the Trpc1 gene. Ca(2+) release-activated currents (ICRAC) were identified by ion permeability, voltage dependence, and sensitivity to selective Orai antagonists Synta66 and GSK7975A. Depletion-evoked calcium influx was initiated at the Müller end-foot and apical process, triggering centrifugal propagation of Ca(2+) waves into the cell body. EM analysis of the end-foot compartment showed high-density ER cisternae that shadow retinal ganglion cell (RGC) somata and axons, protoplasmic astrocytes, vascular endothelial cells, and ER-mitochondrial contacts at the vitreal surface of the end-foot. The mouse retina expresses transcripts encoding both Stim and all known Orai genes; Müller glia predominantly express stromal interacting molecule 1 (STIM1), whereas STIM2 is mainly confined to the outer plexiform and RGC layers. Elimination of TRPC1 facilitated Müller gliosis induced by the elevation of intraocular pressure, suggesting that TRPC channels might play a neuroprotective role during mechanical stress. By characterizing the properties of store-operated signaling pathways in Müller cells, these studies expand the current knowledge about the functional roles these cells play in retinal physiology and pathology while also providing further evidence for the complexity of calcium signaling mechanisms in CNS astroglia.Vir: The Journal of neuroscience. - ISSN 0270-6474 (Vol. 36, iss. 11, Mar. 2016, str. 3184-3198)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2016Jezik - angleškiCOBISS.SI-ID - 33089241
Avtor
Molnar, Tünde |
Yarishkin, Oleg |
Iuso, Anthony |
Barabas, Peter |
Jones, Bryan |
Marc, Robert E. |
Phuong, Tam T. T. |
Križaj, David
Teme
reactive gliosis |
calcium |
TRPC |
reaktivna glioza |
kalcij |
TRPC
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Molnar, Tünde | ![]() |
Yarishkin, Oleg | ![]() |
Iuso, Anthony | ![]() |
Barabas, Peter | ![]() |
Jones, Bryan | ![]() |
Marc, Robert E. | ![]() |
Phuong, Tam T. T. | ![]() |
Križaj, David | 07133 |
Vir: Osebne bibliografije
in: SICRIS
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