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  • FBXO3 protein promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator)
    Shao, Wei ...
    The autoimmune regulator (AIRE) is a transcription factor which is expressed in medullary thymic epithelial cells. It directs the expression of otherwise tissue-specific antigens, which leads to the ... elimination of autoreactive T cells during development. AIRE is modified post-translationally by phosphorylation and ubiquitylation. In this report we connected these modifications. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiq- uitin ligase. In turn, this SCF FBXO3 (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive tran- scription elongation factor b (P-TEFb), and potentiates its transcriptional activity. Because P-TEFb is required for the transition from initiation to elongation of transcription, this interaction ensures proper expression of AIRE-responsive tissue-specific antigens in the thymus.
    Vir: The Journal of biological chemistry. - ISSN 0021-9258 (Vol. 291, iss. 34, Aug. 2016, str. 17953-17963)
    Vrsta gradiva - članek, sestavni del
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 33120473

    Povezava(-e):

    http://www.jbc.org/content/291/34/17953.full.pdf
    DOI

vir: The Journal of biological chemistry. - ISSN 0021-9258 (Vol. 291, iss. 34, Aug. 2016, str. 17953-17963)
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