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Toxicity by NSAIDs : counteraction by stable gastric pentadecapeptide BPC 157Sikirić, Predrag ...Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, ... stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157 beneficial effects on stomach, duodenum, intestine, liver and brain injuries, adjuvant arthritis, pain, hyper/hypothermia, obstructive thrombus formation and thrombolysis, blood vessel function, counteraction of prolonged bleeding and thrombocytopenia after application of various anticoagulants and antiplatelet agents and wound healing improvement. The arguments for BPC 157 antidote activity (i.e., the role of BPC 157 in cytoprotection, being a novel mediator of Robert's cytoprotection and BPC 157 beneficial effects on NSAIDs mediated lesions in the gastrointestinal tract, liver and brain and finally, counteraction of aspirin-induced prolonged bleeding and thrombocytopenia) obviously have a counteracting effect on several established side-effects of NSAIDs use. The mentioned variety of the beneficial effects portrayed by BPC 157 may well be a foundation for establishing BPC 157 as a NSAIDs antidote since no other single agent has portrayed a similar array of effects. Unlike NSAIDs, a very high safety (no reported toxicity (LD1 could be not achieved)) profile is reported for BPC 157. Also, unlike the different dosage levels of aspirin, as a NSAIDs prototype, which differ by a factor of about ten, all these beneficial and counteracting effects of BPC 157 were obtained using the equipotent dosage ([micro]g, ng/kg) in parenteral or peroral regimens.Vir: Current pharmaceutical design. - ISSN 1381-6128 (iss. 1, Vol. 19, 2013, str. 76-83)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2013Jezik - angleškiCOBISS.SI-ID - 34197209
Avtor
Sikirić, Predrag |
Seiwerth, Sven |
Ručman, Rudolf, 1940- |
Turkovic, Branko |
Stančić-Rokotov, Dinko |
Brčić, Luka |
Sever, Marko, 1981- |
Klicek, Robert |
Radic, Bozo |
Kolenc, Danijela
Teme
NSAIDs-gastrointestinal tract lesions |
NSAIDs-liver lesions |
pentadecapeptide BPC 157 |
NSAID-lezije gastrointestinalnega trakta |
NSAID-jetrne spremembe |
pentadekaptid BPC 157
Vnos na polico
Trajna povezava
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Sikirić, Predrag | |
Seiwerth, Sven | |
Ručman, Rudolf, 1940- | 09952 |
Turkovic, Branko | |
Stančić-Rokotov, Dinko | |
Brčić, Luka | |
Sever, Marko, 1981- | |
Klicek, Robert | |
Radic, Bozo | |
Kolenc, Danijela | 52857 |
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