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  • Mutagenicity and DNA damage of bisphenol A and its structural analogs = Mutagenost in poškodbe DNA povzročene z bisfenolom A in njegovimi strukturnimi analogi
    Fic, Anja ...
    An environmental estrogen, bisphenol A (BPA), and its analogs are widespread in our living environment. Because their production and use are increasing, exposure of humans to bisphenols is becoming a ... significant issue. We evaluatedthe mutagenic and genotoxic potential of eight BPA structural analogs(BPF, BPAF, BPZ, BPS, DMBPA, DMBPS, BP-1 and BP-2), with Ames and cometassays, respectively. None of the tested bisphenols (0.004, 0.02, 0.1 and0.5 mg/plate) showed a mutagenic effect in Salmonella typhimurium strains TA98 and TA100, in either the presence or absence of external S9-mediated metabolic activation (Aroclor 1254-induced male rat liver). The potential genotoxicity of bisphenols was determined in the human hepatoma cell line (HepG2) at non-cytotoxic concentrations (0.1 - 10 ŽM) after 4 and 24 h exposure. In the comet assay, BPA and its analog BPS induced significant DNA damage only after 24 h exposure, while analogs DMBPS, BP-1 and BP-2 induced transient increase in DNA strand breaks observed only after 4 h exposure. BPF,BPAF, BPZ and DMBPA did not induce DNA damage in the applied experimental conditions.
    Vir: Arhiv za higijenu rada i toksikologiju = Archives of industrial hygiene and toxicology. - ISSN 0004-1254 (Vol. 64, no. 2, 2013, str. 189-200)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 3437937

    Povezava(-e):

    http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=152768
    DOI

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