VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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High FREM2 gene and protein expression are associated with favorable prognosis of IDH-WT glioblastomas [Elektronski vir]Jovchevska, Ivana ...World Health Organization grade IV diffuse gliomas, known as glioblastomas, are the most common malignant brain tumors, and they show poor prognosis. Multimodal treatment of surgery followed by ... radiation and chemotherapy is not sufficient to increase patient survival, which is 12 to 18 months after diagnosis. Despite extensive research, patient life expectancy has not significantly improved over the last decade. Previously, we identified FREM2 and SPRY1 as genes with differential expression in glioblastoma cell lines compared to nonmalignant astrocytes. In addition, the FREM2 and SPRY1 proteins show specific localization on the surface of glioblastoma cells. In this study, we explored the roles of the FREM2 and SPRY1 genes and their proteins in glioblastoma pathology using human tissue samples. We used proteomic, transcriptomic, and bioinformatics approaches to detect changes at different molecular levels. We demonstrate increased FREM2 protein expression levels in glioblastomas compared to reference samples. At the transcriptomic level, both FREM2 and SPRY1 show increased expression in tissue samples of different glioma grades compared to nonmalignant brain tissue. To broaden our experimental findings, we analyzed The Cancer Genome Atlas glioblastoma patient datasets. We discovered higher FREM2 and SPRY1 gene expression levels in glioblastomas compared to lower grade gliomas and reference samples. In addition, we observed that low FREM2 expression was associated with progression of IDH-mutant low-grade glioma patients. Multivariate analysis showed positive association between FREM2 and favorable prognosis of IDH-wild type glioblastoma. We conclude that FREM2 has an important role in malignant progression of glioblastoma, and we suggest deeper analysis to determine its involvement in glioblastoma pathology.Vir: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 11, 2019, str. 1-18)Vrsta gradiva - e-članekLeto - 2019Jezik - angleškiCOBISS.SI-ID - 34433753
Avtor
Jovchevska, Ivana |
Zottel, Alja |
Šamec, Neja, 1983- |
Mlakar, Jernej, dr. med., spec. patologije |
Sorokin, Maxim |
Nikitin, Daniil |
Buzdin, Anton A. |
Komel, Radovan
Teme
glioblastoma |
malignancy |
FREM2 |
SPRY1 |
TCGA |
glioblastom |
malignost
Vnos na polico
Trajna povezava
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Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Jovchevska, Ivana | 38279 |
Zottel, Alja | 39126 |
Šamec, Neja, 1983- | 33735 |
Mlakar, Jernej, dr. med., spec. patologije | 54927 |
Sorokin, Maxim | |
Nikitin, Daniil | |
Buzdin, Anton A. | |
Komel, Radovan | 06135 |
Vir: Osebne bibliografije
in: SICRIS
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