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Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma [Elektronski vir]Kranjc Brezar, Simona ...in a favorable prognosis for HPV-positive patients treated with radiation alone or with concurrent platinum-based chemotherapy. The degree of radiosensitivity in fractionated regimens has not yet ... been fully explored; therefore, in this study, the radiosensitivity of HPV-negative tumors (FaDu) was compared to that of HPV-positive tumors (2A3) subjected to concurrent cisplatin chemotherapy and fractionated versus isoeffective single-dose tumor irradiation in immunodeficient mice. HPV-positive tumors were approximately 5 times more radiosensitive than HPV-negative tumors, irrespective of the irradiation regimen. In both tumor models, concurrent cisplatin chemotherapy and the fractionated regimen induced significant tumor radiosensitization, with a 3- to 4-fold increase in the tumor growth delay compared to that of single-dose irradiation. Furthermore, the degree of radiosensitization induced by cisplatin chemotherapy concurrent with the fractionated irradiation regimen was much higher in HPV-positive tumors, where a synergistic antitumor effect was observed. Specifically, after combined therapy, a 26% higher survival rate was observed in mice with HPV-positive tumors than in mice with HPV-negative tumors. These data suggest that HPV-positive tumors are more radiosensitive to fractionated regimen than to single-dose irradiation with concurrent cisplatin chemotherapy acting synergistically to irradiation.Vir: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 10, 2020, str. [1-9])Vrsta gradiva - e-članekLeto - 2020Jezik - angleškiCOBISS.SI-ID - 3455611
Avtor
Kranjc Brezar, Simona |
Prevc, Ajda |
Nikšić Žakelj, Martina |
Brožič, Andreja |
Čemažar, Maja |
Strojan, Primož |
Serša, Gregor
Teme
cisplatin |
kemoterapija |
ploščatocelični rak |
rak glave in vratu |
eksperimentalna onkologija |
cisplatin |
chemotherapy |
squamous cell carcinoma |
oropharyngeal cancer |
experimental oncology
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kranjc Brezar, Simona | 19058 |
Prevc, Ajda | 37415 |
Nikšić Žakelj, Martina | 38225 |
Brožič, Andreja | 35354 |
Čemažar, Maja | 14575 |
Strojan, Primož | 14576 |
Serša, Gregor | 08800 |
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