-
Screening of TERC gene amplification as an additional genetic diagnostic test in detection of cervical preneoplastic lesionsKokalj-Vokač, Nadja ...TERC gene amplification was investigated as a possible diagnostic marker for use in routine cytological screening to improve the accuracy of conventional screening procedures in detection of cervical ... preneoplastic lesions. Cervical smears were screened and classified as low-grade or high-grade squamous intraepithelial lesions (LSIL or HSIL). A fluorescence in situ hybridization procedure using a TERC-specific DNA probe was performed on the same specimens and TERC gene copy number was evaluated. More than two signals per cell were defined as TERC positive. In cervical smears graded after conization as cervical intraepithelial neoplasia grade 1 (CIN 1), no TERC-positive cases were found in either LSIL or HSIL, and no TERC amplification was found in LSILcases with histological results CIN 1 and CIN 2. Amplifications of the TERC gene first appeared in HSIL cases with CIN 2 histology. In the CIN 3 group, TERC-positive cases were present in both LSIL and HSIL; in these, therewere no statistically significant differences between TERC-positive and TERC-negative cases. Statistically significant differences in TERC-positive cases were found between LSIL and HSIL without regard to the CIN grade. From the results obtained, it can be concluded that TERC gene amplifications inevitably lead to a high risk of CIN 3 in both LSIL and HSIL after cytological smear examination. A high CIN grade is not necessarily correlated with TERC amplification, but a positive TERC result certainly demands a high CIN classification.Vir: Cancer genetics and cytogenetics. - ISSN 0165-4608 (Vol. 195, no. 1, 2009, str. 19-22)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2009Jezik - angleškiCOBISS.SI-ID - 3500607
Avtor
Kokalj-Vokač, Nadja |
Kodrič, Tatjana, 1946- |
Erjavec Škerget, Alenka, 1974- |
Zagorac, Andreja |
Takač, Iztok
Teme
Cervical Intraepithelial Neoplasia |
diagnosis |
genetics |
pathology |
Cervikalna intraepitelna neoplazija |
Diagnostika |
Genetika |
Patologija |
Uterine Cervical Dysplasia |
diagnosis |
genetics |
pathology |
Maternični vrat, displazija |
Diagnostika |
Genetika |
Patologija |
Telomerase |
Telomeraza |
Gene Amplification |
Gen, amplifikacija |
In Situ Hybridization, Fluorescence |
In situ hibridizacija, fluorescenčna |
Genome, Human |
Človeški genom |
RNA |
genetics |
RNA |
Genetika |
Early Detection of Cancer |
Zgodnje odkrivanje raka
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Kokalj-Vokač, Nadja | 13343 |
Kodrič, Tatjana, 1946- | 05332 |
Erjavec Škerget, Alenka, 1974- | 20135 |
Zagorac, Andreja | 15747 |
Takač, Iztok | 01324 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.