VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Influence of fever on cefazolin pharmacokinetics
    Beović, Bojana ...
    The influence of fever on the pharmacokinetics of cefazolin was investigated in patients with acute febrile diseases. Nine patients were included in the study. Antibiotic serum concentration were ... determined using high performance liquid chromatography (HPLC). An analog computer and the SIMULINK software package were used to identify the pharmacokinetic model and PCNONLIN software package to obtain the secondary parameters. In 6 patients a two-compartment pharmacokinetic model of cefazolin was observed during fever and after defeverescence. In 2 patients a two-compartment model changed to a one-compartment after defeverescence, and a one-compartment model was observed in one patient during both periods. Cefazolin-treated patients with a two-compartment model (6/9) had higher Cmax, mean steady state serum concentrations (Css) and area under the plasma concetration-time curve (AUC(0-- >infinity)), smaller central compartment volume (V1), and lower clearance (Cl) during fever. The varying distribution of antibiotics fever probably reflects different hemodynamic responses to fever.
    Vir: Journal of chemotherapy. - ISSN 1120-009X (Vol. 11, no. 1, 1999, str. 40-45)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 1999
    Jezik - angleški
    COBISS.SI-ID - 351089

vir: Journal of chemotherapy. - ISSN 1120-009X (Vol. 11, no. 1, 1999, str. 40-45)
loading ...
loading ...
loading ...

Vnos na polico