VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening
    Švajger, Urban ...
    Toll-like receptor 4 (TLR4) in complex with its accessory protein MD-2 represents an emerging target for the treatment of severe sepsis and neuropathic pain. We performed structure-based and ... ligand-based virtual screening targeting the TLR4-MD-2 interface. Three in silico hit compounds showed promising TLR4 antagonistic activities with micromolar IC50 values. These compounds also suppressed cytokine secretion by human peripheral blood mononuclear cells. The specific affinity of the most potent hit was confirmed by surface plasmon resonance direct-binding experiments. The results of our study represent a very promising starting point for the development of potent small-molecule antagonists of TLR4.
    Vir: European journal of medicinal chemistry. - ISSN 0223-5234 (Vol. 70, Dec. 2013, str. 393-399)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 3538289

    Povezava(-e):

    http://www.sciencedirect.com/science/journal/aip/02235234
    http://www.sciencedirect.com/science/article/pii/S0223523413006600
    DOI

Vnos na polico