VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Action of clathrodin and analogues on voltage-gated sodium channels [Elektronski vir]
    Peigneur, Steve ...
    Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, ... clathrodin could representan interesting lead compound. Therefore, clathrodin was reinvestigated for its potency and NaV channel subtype selectivity. Clathrodin and its synthetic analogues were subjected to screening on a broad range of NaV channel isoforms, both in voltage clamp and patch clamp conditions. Even though clathrodin was not found to exert any activity, some analogues were capable of modulating the NaV channels, hereby validating the pyrrole-2-aminoimidazole alkaloid structure as a core structure for future small molecule-based NaV channel modulators.
    Vir: Marine drugs [Elektronski vir]. - ISSN 1660-3397 (Vol. 12, no. 4, 2014, str. 2132-2143)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 3629681

    Povezava(-e):

    http://www.mdpi.com/1660-3397/12/4/2132
    Repozitorij Univerze v Ljubljani – RUL
    DOI

Vnos na polico