VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Thermoresponsive polymers: Insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications
    Radivojša Matanović, Maja ; Kristl, Julijana ; Ahlin Grabnar, Pegi
    Thermally induced gelling systems have gained enormous attention over the last decade. They consist of hydrophilic homopolymers or block copolymers in water that present a sol at room temperature and ... form a gel after administration into the body. This article reviews the main types of thermo responsive polymers, with special focus on decisive hydrogel characteristics, mechanisms of gelation, and biocompatibility. Promising biomedical applications are described with a focus on injectable formulations,which include solubilization of small hydrophobic drugs, controlled release, delivery of labile biopharmaceutics, such as proteins and genes, cell encapsulation, and tissue regeneration. Furthermore, combinations of thermoresponsive hydrogels and various nanocarriers as promising systems for sustained drug delivery are discussed through selected examples from the literature. Finally, there is a brief overview of current progress in nano-sized systems incorporating thermoresponsive properties.
    Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 472, iss. 1-2, Sep. 2014, str. 262-275)
    Vrsta gradiva - članek, sestavni del
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 3672945

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0378517314004499#
    http://ac.els-cdn.com/S0378517314004499/1-s2.0-S0378517314004499-main.pdf?_tid=d26bf658-fab0-11e3-81fa-00000aab0f6b&acdnat=1403512490_2784721d98bca47a053a1786f993f249
    DOI

vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 472, iss. 1-2, Sep. 2014, str. 262-275)
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