VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Nanomechanical properties of selected single pharmaceutical crystals as a predictor of their bulk behaviour
    Egart, Mateja, farmacevtka ...
    The main goal of this research was to assess the mechanical properties of APIsʼ polymorphic forms at the single-crystal level (piroxicam, famotidine, nifedipine, olanzapine) in order to predict their ... bulk deformational attributes, which are critical for some pharmaceutical technology processes. The mechanical properties of oriented single crystals were determined using instrumented nanoindentation (continuous stiffness measurement). All polymorphic forms investigated were previously identified using a combination of calorimetric and spectroscopic techniques. Mechanical properties such as Youngʼs modulus and indentation hardness were consistent with the molecular packing of the polymorphic forms investigated with respect to crystal orientation. For mechanically interlocked structures, characteristic of most polymorphic forms, response of single crystals to indentation was isotropic. The materialʼs bulk elastic properties can be successfully predicted by measuring Youngʼs modulus of single crystals because a good linear correlation with a bulk parameter such as the tabletsʼ elastic relaxation index was determined. The results confirm the idea that the intrinsic mechanical properties of pharmaceutical crystals (Youngʼs modulus) largely control and anticipate their deformational behavior during tablet compression.Youngʼs modulus and indentation hardness represent a very valuable and effective tool in preformulation studies for describing materialsʼmechanical attributes, which are important for technological processes in which materials are exposed to deformation.
    Vir: Pharmaceutical research. - ISSN 0724-8741 (Vol. 32, no. 2, 2015, str. 469-481)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 3691377

    Povezava(-e):

    https://link.springer.com/article/10.1007/s11095-014-1475-3
    DOI

vir: Pharmaceutical research. - ISSN 0724-8741 (Vol. 32, no. 2, 2015, str. 469-481)
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