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  • Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells [Elektronski vir]
    Perišić, Milica ...
    Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed ... constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes.
    Vir: Frontiers in immunology. - ISSN 1664-3224 (Vol. 5, 2014, art. 616)
    Vrsta gradiva - e-članek
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 3788913

    Povezava(-e):

    http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full
    http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full
    DOI

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