VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
Celotno besedilo
  • Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S
    Fic, Anja ...
    The bisphenols AF (BPAF) and S (BPS) are structural analogs of the endocrine disruptor bisphenol A (BPA), and are used in common products as a replacement for BPA. To elucidate genome-wide gene ... expression responses, estrogen-dependent osteosarcoma cells were cultured with 10 nM BPA, BPAF, or BPS, for 8 h and 3 months. Genome-wide gene expression was analyzed using the Illumina Expression BeadChip. Three months exposure had significant effects on gene expression, particularly for BPS, followed by BPAF and BPA, according to the number of differentially expressed genes (1980, 778, 60, respectively),the magnitude of changes in gene expression, and the number of enriched biological processes (800, 415, 33, respectively) and pathways (77, 52, 6, respectively). ŽEmbryonic skeletal system developmentʼ was the most enriched bone-related process, which was affected only by BPAF and BPS. Interestingly, all three bisphenols showed highest down-regulation of genes related to the cardiovascular system (e.g., NPPB, NPR3, TXNIP). BPA only and BPA/BPAF/BPS also affected genes related to the immune system and fetal development, respectively. For BPAF and BPS, the Žisoprenoid biosynthetic processʼ was enriched (up-regulated genes: HMGCS1, PDSS1, ACAT2, RCE1, DHDDS).Compared to BPA, BPAF and BPS had more effects on gene expression afterlong-term exposure. These findings stress the need for careful toxicological characterization of BPA analogs in the future.
    Vir: Toxicology in vitro. - ISSN 0887-2333 (Vol. 29, iss. 5, Apr. 2015, str. 1060-1069)
    Vrsta gradiva - članek, sestavni del
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 3849841
vir: Toxicology in vitro. - ISSN 0887-2333 (Vol. 29, iss. 5, Apr. 2015, str. 1060-1069)
loading ...
loading ...