VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • D-Glucosamine in iron-catalysed cross-coupling reactions of Grignards with allylic and vinylic bromides : application to the synthesis of a key sitagliptin precursor
    Sova, Matej, 1979- ...
    A sustainable D-glucosamine ligand is successfully introduced into iron-catalysed C[BOND]C cross-coupling reactions for the first time. The Fe(acac)2/D-glucosamine-HCl/Et3N catalytic system was ... effective at 5 mol% loading in coupling reactions of Grignard reagents with organic bromides. Moderate to high efficiency was achieved with preserved stereochemistry when allyl (Csp3) or alkenyl (Csp2) bromides were coupled with phenylmagnesium (Csp2) or benzylmagnesium (Csp3) bromides. The catalytic system developed was also successfully applied for the novel and economic preparation of a Michael-acceptor-like starting material used in an alternative synthesis of the drug sitagliptin, a known blockbuster for the treatment of type II diabetes mellitus.
    Vir: Applied organometallic chemistry. - ISSN 0268-2605 (Vol. 29, issue 8, 2015, str. 528-535)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 3870833

    Povezava(-e):

    http://onlinelibrary.wiley.com/doi/10.1002/aoc.3327/abstract
    DOI

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