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  • Determination of solubility parameters of ibuprofen and ibuprofen lysinate
    Kitak, Teja ...
    In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable ... problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansenʼs approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansenʼs approach it was [gamma]t=31.15 MPa0.5 and with IGC it was [gamma]t = 35.17 MPa0.5. However, the values of partial solubility parameters, i.e., [gamma]d, [gamma]p and [gammah, differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.
    Vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 20, iss. 12, 2015, str. 21549-21568)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 3983985

vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 20, iss. 12, 2015, str. 21549-21568)
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