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Shelf life after opening of prescription medicines and supplements with vitamin D3 for paediatric useTemova Rakuša, Žane ; Roškar, Robert, 1975-Objectives: The aim of this study was to evaluate the effect of storage conditions on the shelf life of liquid pharmaceuticals with vitamin D3 in order to determine appropriate storage conditions and ... shelf life after the product has been opened. Manufacturers rarely specify the shelf life after products have been opened, which leads to a controversial debate among medical professionals regarding the safety of products after opening and optimal storage conditions and considerably different recommendations to the public. Methods: Effect of storage conditions on the shelf life was evaluated by comparing the isothermal stability of vitamin D3 in three prescription and three non-prescription medicines at different temperatures (4°C, 25°C and 40°C) using stability-indicating high performance liquid chromatography assay. Results: Most of the examined preparations had a higher vitamin D3 content than the label claim when the products were first opened, presumably to compensate for loss during production and storage. An association was observed between the initial vitamin D3 content and its stability in the preparations. The vitamin D3 overage in liquid prescription medicines guaranteed its content >90 of the amount claimed on the label for at least 1year when stored at 25°C and for 4months at 40°C. All tested preparations are consumed when used as recommended over this period. Since some manufacturers recommend storage below room temperature, redefining the storage conditions is of practical significance. Conclusions: The shelf life after opening examined prescription medicines containing vitamin D3 as their main active ingredient is at least 1 year at room temperature.Vir: European journal of hospital pharmacy. Science and practice. - ISSN 2047-9956 (Vol. 24, iss. 2, 2017, str. 115-119)Vrsta gradiva - članek, sestavni delLeto - 2017Jezik - angleškiCOBISS.SI-ID - 4072305
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vir: European journal of hospital pharmacy. Science and practice. - ISSN 2047-9956 (Vol. 24, iss. 2, 2017, str. 115-119)
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Temova Rakuša, Žane | 38166 |
Roškar, Robert, 1975- | 23549 |
Vir: Osebne bibliografije
in: SICRIS
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