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  • Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's disease
    Dgachi, Youssef ...
    We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative ... properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC50 = 1.28 % 0.03 microM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line.
    Vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 21, iss. 5, 2016, str. 1-15)
    Vrsta gradiva - članek, sestavni del
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 4083825