VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Risk factors for the development of high-grade dysplasia and carcinoma in patients with laryngeal squamous cell papillomas : large retrospective cohort study
    Gluvajić, Daša ...
    The incidence and risk factors for the development of high-grade dysplasia (HG-D) and laryngeal squamous cell carcinoma (LSCC) were assessed in patients with laryngeal squamous cell papillomas (LSP). ... Methods Clinical data, human papillomaviruses (HPV) typing, HPV E6/E7 mRNA in situ hybridization, and sequencing of host genes in LSP biopsies of 163 patients were analyzed. Results Progression to HG-D and LSCC was identified in 21.5% and 4.3% of LSP patients, respectively. A more advanced age at LSP onset and lack of HPV infection were detected as risk factors for the development of HG-D and LSCC (P <.05). The identification of HG-D was associated with its progression to LSCC (P <.05). Host gene mutations were identified in 3 of 7 patients with LSCC. Conclusions The histological monitoring of LSP and HPV typing are necessary for early detection of epithelial changes. Further research is needed to elucidate the role of host gene mutations in LSCC transformation.
    Vir: Head and neck. - ISSN 1043-3074 (Vol. 43, no. 3, Mar. 2021, str. 956-966)
    Vrsta gradiva - članek, sestavni del
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 40900099
    DOI

vir: Head and neck. - ISSN 1043-3074 (Vol. 43, no. 3, Mar. 2021, str. 956-966)
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