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  • Virus attenuation after deletion of the cytomegalovirus Fc receptor gene is not due to antibody control
    Crnković-Mertens, Irena ...
    The murine cytomegalovirus (MCMV) fcr-1 codes for a glycoprotein located at the surface of infected cells which strongly binds the Fc fragment of murine immunoglobulin G. To determine the biological ... significance of the fcr-1 gene during viral infection, we constructed MCMV fcr-1 deletion mutants and revertants. The fcr-1 gene was disrupted by insertion of the Escherichia coli lacZ gene. In another mutant, the marker gene was also deleted, by recombinase cre. As expected for its hypothetical role in immunoevasion, the infection of mice with fcr-1 deletion mutants resulted in significantly restricted replication in comparison with wild wild-type MCMV and revertant virus. In mutant mice lacking antibodies, however, the fcr-1 deletion mutants also replicated poorly. This demonstrated that the cell surface-expressed viral glycoprotein with FcR activity strongly modulates the virus-host interaction but this biological function is not caused by the immunoglobulin binding property.
    Vir: Journal of virology. - ISSN 0022-538X (Letn. 72, št. 2, 1998, str. 1377-1382)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 412067

vir: Journal of virology. - ISSN 0022-538X (Letn. 72, št. 2, 1998, str. 1377-1382)
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