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  • Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity
    Mitrović, Ana ...
    Over the past years, the organometalled compounds, including ruthenium, gained a lot of attention as anticancer agents. We report on clioquinol-ruthenium complex [Ru(eta6-p-cymene)(Cq)Cl] as a potent ... inhibitor of cathepsin B, a lysosomal cysteine peptidase, involved in tumour cell invasion and metastasis. In the low micromolar concentration range, clioquinol-ruthenium complex did not exhibit cytotoxic effects on MCF-10A neoT and U-87 MG cells; it did, however, significantly reduced their ability for extracellular matrix degradation and invasiveness in two independent cell-based models, measuring either electrical impedance in real time or the growth of multicellular tumour spheroids implanted in Matrigel, a model representing the extracellular matrix. These results establish ruthenium based organometallic compounds as promising candidates for further pre-clinical studies as anticancer therapeutics.
    Vir: Dalton transactions. - ISSN 1477-9226 (Vol. 45, iss. 42, 2016, str. 16913-16921)
    Vrsta gradiva - članek, sestavni del
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 4164977

    Povezava(-e):

    http://pubs.rsc.org/en/content/articlelanding/2016/dt/c6dt02369j#!divAbstract
    DOI

vir: Dalton transactions. - ISSN 1477-9226 (Vol. 45, iss. 42, 2016, str. 16913-16921)
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