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  • Novel spray dried glycerol 2-phosphate cross-linked chitosan microparticulate vaginal delivery system - development, characterization and cytotoxicity studies [Elektronski vir]
    Szymańska, Emilia ...
    Chitosan microparticulate delivery systems containing clotrimazole were prepared by a spray drying technique using glycerol 2-phosphate as an ion cross-linker. The impact of a cross-linking ratio on ... microparticle characteristics was evaluated. Drug-free and drug-loaded unmodified or ion cross-linked chitosan microparticles were examined for the in vitro cytotoxicity in VK2/E6E7 human vaginal epithelial cells. The presence of glycerol 2-phosphate influenced drug loading and encapsulation efficacy in chitosan microparticles. By increasing the cross-linking ratio, the microparticles with lower diameter, moisture content and smoother surface were observed. Mucoadhesive studies displayed that all formulations possessed mucoadhesive properties. The in vitro release profile of clotrimazole was found to alter considerably by changing the glycerol 2-phosphate/chitosan ratio. Results from cytotoxicity studies showed occurrence of apoptotic cells in the presence of chitosan and ion cross-linked chitosan microparticles, followed by a loss of membrane potential suggesting that cell death might go through the mitochondrial apoptotic pathway.
    Vir: Marine drugs [Elektronski vir]. - ISSN 1660-3397 (Vol. 14, no. 10, 2016, 22 str.)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 4190065

    Povezava(-e):

    http://www.mdpi.com/1660-3397/14/10/174
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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