Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions : a prospective cohort studyMuhič, Neža ; Mrhar, Aleš ; Brvar, MiranPurpose Drug-drug interaction (DDI) screening systems report potential DDIs. This study aimed to find the prevalence of probable DDI-related adverse drug reactions (ADRs) and compare the clinical ... usefulness of different DDI screening systems to prevent or warn against these ADRs. Methods A prospective cohort study was conducted in patients urgently admitted to medical departments. Potential DDIs were checked using Complete Drug Interaction, Lexicomp Online, and Drug Interaction Checker. The study team identified the patients with probable clinically relevant DDI-related ADRs on admission, the causality of which was assessed using the Drug Interaction Probability Scale (DIPS). Sensitivity, specificity, and positive and negative predictive values of screening systems to prevent or warn against probable DDI-related ADRs were evaluated. Results Overall, 50 probable clinically relevant DDI-related ADRs were found in 37 out of 795 included patients taking at least two drugs, most common of them were bleeding, hyperkalemia, digitalis toxicity, and hypotension. Complete Drug Interaction showed the best sensitivity (0.76) for actual DDI-related ADRs, followed by Lexicomp Online (0.50), and Drug Interaction Checker (0.40). Complete Drug Interaction and Drug Interaction Checker had positive predictive values of 0.07; Lexicomp Online had 0.04. We found no difference in specificity and negative predictive values among these systems. Conclusion DDI screening systems differ significantly in their ability to detect probable clinically relevant DDI-related ADRs in terms of sensitivity and positive predictive value. Keywords Actual drug-drug interactionsPotential drug-drug interactionsAdverse drug reactions Drug-drug interaction screening systemsVir: European Journal of Clinical Pharmacology. - ISSN 0031-6970 (Vol. 73, iss. 7, 2017, str. 875-882)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2017Jezik - angleškiCOBISS.SI-ID - 4298865
Vnos na polico
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Baze podatkov, v katerih je revija indeksirana
|Ime baze podatkov||Področje||Leto|
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
|Mesto prevzema||Status gradiva||Rezervacija|
Prosimo, počakajte trenutek.