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  • Free radicals and intrinsic skin aging : basic principles
    Gošnak Dahmane, Raja ; Poljšak, Borut, 1976-
    Generally speaking intrinsic aging depends on time but in fact it depends rather on free radical metabolism kinetics as well as on efficacy of the skin cells defence and repair systems. Although the ... fundamental mechanisms of skin aging are still poorly understood, research points towards reactive oxygen species (ROS) as one of the primary determinants of skin aging. It is probable that oxidative damage is the single most damaging contributor to skin aging leading to nuclear and mitochondrial DNA damage, telomere shortening, protein glycosylation, lipid and protein oxidation, collagen and elastin degradation, down-regulation of collagen synthesis, increased expression of matrix metalloproteinases, neovascularization. Radical-scavenging antioxidants can neutralize ROS and antioxidant status could play an important role in intrinsic skin aging.
    Vir: HealthMed. - ISSN 1840-2291 (Vol. 5, no. 6, 2011, str. 1647-1654)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 4309611
    DOI

vir: HealthMed. - ISSN 1840-2291 (Vol. 5, no. 6, 2011, str. 1647-1654)
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